Enables BMP binding activity; BMP receptor binding activity; and heparan sulfate proteoglycan binding activity. Involved in imaginal disc-derived wing vein specification and positive regulation of BMP signaling pathway. Located in extracellular region. Is expressed in several structures, including anterior-posterior compartment boundary of imaginal disc; eye disc posterior to the morphogenetic furrow; notopleural bristle; wing disc; and wing vein. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator).
FB Description
crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo.