Gene

cv-2

Species
Drosophila melanogaster
Symbol
cv-2
Name
crossveinless 2
Synonyms
  • BMPER
  • CG15671
Biotype
protein coding gene
Automated Description
Enables BMP binding activity; BMP receptor binding activity; and heparan sulfate proteoglycan binding activity. Involved in imaginal disc-derived wing vein specification and positive regulation of BMP signaling pathway. Located in extracellular region. Is expressed in several structures, including anterior-posterior compartment boundary of imaginal disc; eye disc posterior to the morphogenetic furrow; notopleural bristle; wing disc; and wing vein. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator).
FB Description
crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46698
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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21.356M21.358M21.360M21.362M21.364M21.366M21.368M21.370M21.372M21.374M21.376M21.378M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions