Enables A-type (transient outward) potassium channel activity. Involved in associative learning and chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic hindgut; ganglia; larval muscle system; and larval visceral muscle cell. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to several human genes including KCND3 (potassium voltage-gated channel subfamily D member 3).
FB Description
Shaker cognate l (Shal) encodes a voltage-dependent A-type K[+] channel. It contributes to neuronal excitability, regulating synaptic plasticity, locomotion, learning, and lifespan.