Gene

Bin1

Species
Drosophila melanogaster
Symbol
Bin1
Name
Bicoid interacting protein 1
Synonyms
  • 150001_at
  • BcDNA:RE02417
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in heterochromatin formation and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including antennal anlage; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Orthologous to human SAP18 (Sin3A associated protein 18).
FB Description
Bicoid interacting protein 1 (Bin1) interacts with sequence-specific transcription factors (e.g. the product of bcd, Kr, Trl) to help recruit the Sin3A-HDAC1 histone deacetylase co-repressor complex to target genes. The product of Bin1 contributes to axis patterning and embryonic segmentation via transcription regulation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13082
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
16.1865M16.1870M16.1875M16.1880M16.1885M16.1890M16.1895M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions