Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in heterochromatin formation and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including antennal anlage; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Orthologous to human SAP18 (Sin3A associated protein 18).
FB Description
Bicoid interacting protein 1 (Bin1) interacts with sequence-specific transcription factors (e.g. the product of bcd, Kr, Trl) to help recruit the Sin3A-HDAC1 histone deacetylase co-repressor complex to target genes. The product of Bin1 contributes to axis patterning and embryonic segmentation via transcription regulation.