Gene

CAH2

Species
Drosophila melanogaster
Symbol
CAH2
Name
Carbonic anhydrase 2
Synonyms
  • carbonic anhydrase 2
  • CG6906
Biotype
protein coding gene
Automated Description
Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA14 (carbonic anhydrase 14) and CA4 (carbonic anhydrase 4).
FB Description
Carbonic anhydrase 2 (CAH2) encodes an alpha-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18952
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCA43 of 9YesYes   
Homo sapiensCA143 of 9YesYes   
Mus musculusCar44 of 9YesYes   
Mus musculusCar143 of 9NoYes   
Rattus norvegicusCar43 of 9YesYes   
Rattus norvegicusCar143 of 9YesNo   
Xenopus tropicalisXB57972095 of 9YesNo   
Xenopus tropicalisca4.24 of 9NoYes   
Danio rerioca4c4 of 10YesNo  
Danio rerioca4a4 of 10YesNo  
Danio rerioca4b4 of 10YesNo  
Danio reriocar154 of 10YesYes  
Danio reriosi:ch211-173d10.43 of 10NoYes  
Caenorhabditis eleganscah-36 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
CAH7133449317 of 8  
CAH9227851357 of 8  
CAH8328647337 of 8  
CAH1427454366 of 8  
CAH5527050317 of 8  
CAH16628950326 of 8  
CAH6728351336 of 8  
CAH4826552316 of 8  
CARPB931049304 of 8  
CARPA1031844264 of 8  
CAH31124149325 of 8  
CAH151229248273 of 8  
CAH131327648262 of 8  
CAH141424842252 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal developmental rate | parental effect
Showing 1 - 1 of 1 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
12.178M12.179M12.180M12.181M12.182M12.183M2CAH2<MI13837>CAH2<MB07616>CAH2CAH2-RACAH2-RB
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
CAH2MI07079-GFSTF.1
  • CAH2[MI07079-GFSTF.1]
allele with one associated variant
insertion
  • intron variant
CAH2MI13837
  • CAH2[MI13837]
allele with one associated variant
insertion
  • intron variant
CAH2MI07079
  • CAH2[MB07616]
  • CAH2[MI07079]
allele with one associated variant
insertion
  • intron variant
Yes
CAH2MB07616
  • CAH2[MB07616]
allele with one associated variant
insertion
  • 3 prime UTR variant
NT_037436.4:g.12181325C>Tvariant
SNP
  • intron variant
NT_037436.4:g.12178018G>Avariant
SNP
  • intron variant
NT_037436.4:g.12178355C>Gvariant
SNP
  • intron variant
NT_037436.4:g.12178480T>Cvariant
SNP
  • intron variant
NT_037436.4:g.12178571A>Tvariant
SNP
  • intron variant
NT_037436.4:g.12178584C>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 261 rows
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterCAH2GD2438
  • UASt
Drosophila melanogasterCAH2GL01264
  • UAS
Drosophila melanogasterCAH2HMC05961
  • UAS
Drosophila melanogasterCAH2KK104722
  • UASt
Drosophila melanogasterCAH2NIG.6906R
  • UASt
Showing 1 - 5 of 5 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
12.178M12.179M12.180M12.181M12.182M12.183MCAH2-RA (CAH2)CAH2-RB (CAH2)

Sequence Details

Transcript: Mode:
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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
CAH2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG17110Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
Showing 1 - 1 of 1 rows
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Genetic Interactions

No data available