Gene

RNaseZ

Species
Drosophila melanogaster
Symbol
RNaseZ
Name
Ribonuclease Z
Synonyms
  • CG3298
  • dRNase Z
Biotype
protein coding gene
Automated Description
Enables 3'-tRNA processing endoribonuclease activity. Involved in several processes, including RNA processing; germ cell proliferation; and positive regulation of translation. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including embryonic imaginal tissue; female germline cell; gonad; larval imaginal tissue; and somatic precursor cell. Used to study cardiomyopathy and combined oxidative phosphorylation deficiency 17. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2).
FB Description
Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12553
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.3075M10.3080M10.3085M10.3090M10.3095M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions