Gene

SK

Species
Drosophila melanogaster
Symbol
SK
Name
small conductance calcium-activated potassium channel
Synonyms
  • BcDNA:GM01744
  • CG10706
Biotype
protein coding gene
Automated Description
Enables photoreceptor activity and small conductance calcium-activated potassium channel activity. Involved in potassium ion transport and regulation of membrane potential in photoreceptor cell. Located in membrane. Is expressed in several structures, including adult brain; adult head; retina; sensory system neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in myoclonic dystonia 34; paranoid schizophrenia; and schizophrenia. Orthologous to several human genes including KCNN2 (potassium calcium-activated channel subfamily N member 2) and KCNN3 (potassium calcium-activated channel subfamily N member 3).
FB Description
small conductance calcium-activated potassium channel (SK) encodes a potassium channel subunit. Four SK subunits together form a voltage-independent potassium channel, which is activated by intracellular calcium levels and is required for normal photoreceptor light response. Contrary to its mammalian counterpart, Drosophila SK channel is not sensitive to apamin, at least not in photoreceptors.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10153
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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5.35M5.36M5.37M5.38M5.39M5.40M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions