small conductance calcium-activated potassium channel
Synonyms
BcDNA:GM01744
CG10706
Biotype
protein coding gene
Automated Description
Enables photoreceptor activity and small conductance calcium-activated potassium channel activity. Involved in potassium ion transport and regulation of membrane potential in photoreceptor cell. Located in membrane. Is expressed in several structures, including adult brain; adult head; retina; sensory system neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in myoclonic dystonia 34; paranoid schizophrenia; and schizophrenia. Orthologous to several human genes including KCNN2 (potassium calcium-activated channel subfamily N member 2) and KCNN3 (potassium calcium-activated channel subfamily N member 3).
FB Description
small conductance calcium-activated potassium channel (SK) encodes a potassium channel subunit. Four SK subunits together form a voltage-independent potassium channel, which is activated by intracellular calcium levels and is required for normal photoreceptor light response. Contrary to its mammalian counterpart, Drosophila SK channel is not sensitive to apamin, at least not in photoreceptors.