Gene

ihog

Species
Drosophila melanogaster
Symbol
ihog
Name
interference hedgehog
Synonyms
  • CG9211
  • CT26314
Biotype
protein coding gene
Automated Description
Enables several functions, including coreceptor activity; hedgehog family protein binding activity; and heparin binding activity. Involved in several processes, including maintenance of protein location in extracellular region; regionalization; and smoothened signaling pathway. Located in cell surface; cytoneme; and plasma membrane. Is expressed in several structures, including dorsal epidermis primordium; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and imaginal disc. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated) and CDON (cell adhesion associated, oncogene regulated).
FB Description
interference hedgehog (ihog) encodes a type 1 membrane protein that acts as a co-receptor for the product of hh upstream or at the level of the receptor encoded by ptc. It interacts with the products of disp, dlp, dally and shf. It is involved in imaginal pattern formation and embryonic cuticle pattern formation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44170
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            6.9455M6.9460M6.9465M6.9470M6.9475M6.9480M6.9485M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ihog molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              ihog role
              ihog genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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