Enables calcium-activated cation channel activity. Involved in monoatomic cation transport. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87 and hypomyelinating leukodystrophy 19. Orthologous to several human genes including TMEM63A (transmembrane protein 63A).
SGD Description
Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1