Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including determination of adult lifespan; nuclear migration along microtubule; and nuclear pore localization. Located in nuclear envelope and nuclear periphery. Is expressed widely. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to several human genes including LMNA (lamin A/C).
WB Description
lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR.