Gene

mlc-1

Species
Caenorhabditis elegans
Symbol
mlc-1
Name
Myosin Light Chain 1
Synonyms
  • C36E6.3
  • C36E6.f
Biotype
protein coding gene
Automated Description
Predicted to enable myosin heavy chain binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Is expressed in anal depressor muscle; body wall musculature; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 10. Orthologous to several human genes including MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7).
WB Description
mlc-1 encodes a muscle regulatory myosin light chain that is nearly identical to MLC-2 and functions redundantly with MLC-2 in the body-wall and in pharyngeal muscle to affect L1 larval viability, elongation, and pharyngeal and body-wall muscle development, and also affects locomotion and growth; expressed in the body-wall muscles, pharyngeal muscles, and vulval muscles.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23049
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            17.4594M17.4596M17.4598M17.4600M17.4602M17.4604M17.4606M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            mlc-1 molecule type
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              Genetic Interactions

              mlc-1 role
              mlc-1 genetic perturbation
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