Gene

oma-1

Species
Caenorhabditis elegans
Symbol
oma-1
Name
Oocyte MAturation defective 1
Synonyms
  • C09G9.6
  • CELE_C09G9.6
Biotype
protein coding gene
Automated Description
Enables mRNA 3'-UTR AU-rich region binding activity and mRNA regulatory element binding translation repressor activity. Involved in several processes, including digestive tract development; negative regulation of cell differentiation; and oocyte development. Located in P granule and centrosome. Is expressed in several structures, including AB; EMS; head muscle; oocyte; and somatic nervous system. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1) and ZFP36L2 (ZFP36 ring finger protein like 2).
WB Description
oma-1 encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, oma-1 and oma-2 doubly mutant animals show defects in oocyte maturation, indicating that the two genes function redundantly in this process; whereas normal oocytes are released from meiotic prophase I arrest during oocyte maturation, oma-1;oma-2 mutant oocytes initiate, but fail to complete, maturation, arresting at a defined point in meiotic prophase I; the meiotic arrest of oma-1;oma-2 mutant oocytes is suppressed by wee-1.3(RNAi), implying that progression through meiotic prophase I is critically dependent on inhibition of WEE-1.3 by either OMA-1 or OMA-2; OMA-1 is expressed primarily in maturing oocytes, is cytoplasmic and visible prior to cellularization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12547
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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8.8890M8.8892M8.8894M8.8896M8.8898M8.8900M8.8902M8.8904M8.8906M8.8908M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions