Gene

vps-35

Species
Caenorhabditis elegans
Symbol
vps-35
Name
related to yeast Vacuolar Protein Sorting factor 35
Synonyms
  • CELE_F59G1.3
  • F59G1.3
Biotype
protein coding gene
Automated Description
Involved in positive regulation of protein localization to cell periphery; protein localization to postsynaptic membrane; and regulation of presynapse assembly. Located in cytosol; dendrite; and neuronal cell body. Is expressed in several structures, including body wall musculature; ciliated neurons; coelomocyte; intestine; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component).
WB Description
Involved in positive regulation of protein localization to cell periphery; protein localization to postsynaptic membrane; and regulation of presynapse assembly. Located in cytosol; dendrite; and neuronal cell body. Expressed in several structures, including body wall musculature; ciliated neurons; coelomocyte; intestine; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease 17. Is an ortholog of human VPS35 (VPS35 retromer complex component).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11099
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.9080M5.9085M5.9090M5.9095M5.9100M5.9105M5.9110M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions