Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure 70. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2).
WB Description
T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000).