Gene

epg-6

Species
Caenorhabditis elegans
Symbol
epg-6
Name
Ectopic P Granules 6
Synonyms
  • CELE_Y39A1A.1
  • Y39A1A.1
Biotype
protein coding gene
Automated Description
Enables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Is expressed in several structures, including nervous system. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to several human genes including WDR45 (WD repeat domain 45).
WB Description
epg-6 encodes a WD40 repeat-containing protein that is related to the mammalian WIPI3/4 family of proteins (WD40 repeat protein interacting with phosphoinositides); in C. elegans, epg-6 activity is required for autophagic processes, specifically for the formation of autophagosomes from omegasomes (PtdIns(3)P-enriched endoplasmic reticulum subdomains) and for proper distribution of the autophagic proteins ATG-9 and EPG-1; EPG-6 binds ATG-2 in vitro and in vivo and also binds, in vitro, PtdIns(3)P and PtdIns(5)P and weakly binds PtdIns(4)P and PtdIns(3,5)P2; an EGP-6::GFP reporter fusion protein is widely expressed during embryonic and post-embryonic development, and localizes diffusely to the cytoplasm.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11227
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.5970M10.5975M10.5980M10.5985M10.5990M10.5995M10.6000M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions