Enables ATPase inhibitor activity. Predicted to be involved in negative regulation of nucleotide metabolic process. Located in mitochondrion. Is expressed in several structures, including hypodermis; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1).
WB Description
mai-2/B0546.1 is orthologous to mitochondrial intrinsic ATPase inhibitorprotein (IF(1)), which blocks reverse action (ATP hydrolysis) byF(0)F(1)-ATPase when its (normally required) proton gradient is lost;MAI-2 has a mitochondrial import signal at its N-terminus, and istransported to yeast mitochondria; MAI-2 can inhibit yeastF(0)F(1)-ATPase, and this inhibition is pH-dependent; MAI-2's tertiarystructure is dominated by beta-strands and random loops.