Gene

mai-2

Species
Caenorhabditis elegans
Symbol
mai-2
Name
Mitochondrial ATPase Inhibitor family 2
Synonyms
  • 4E151
  • B0546.1
Biotype
protein coding gene
Automated Description
Enables ATPase inhibitor activity. Predicted to be involved in negative regulation of nucleotide metabolic process. Located in mitochondrion. Is expressed in several structures, including hypodermis; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1).
WB Description
mai-2/B0546.1 is orthologous to mitochondrial intrinsic ATPase inhibitorprotein (IF(1)), which blocks reverse action (ATP hydrolysis) byF(0)F(1)-ATPase when its (normally required) proton gradient is lost;MAI-2 has a mitochondrial import signal at its N-terminus, and istransported to yeast mitochondria; MAI-2 can inhibit yeastF(0)F(1)-ATPase, and this inhibition is pH-dependent; MAI-2's tertiarystructure is dominated by beta-strands and random loops.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23407
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.3860M3.3861M3.3862M3.3863M3.3864M3.3865M3.3866M3.3867M3.3868M3.3869M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions