Gene

rpi-2

Species
Caenorhabditis elegans
Symbol
rpi-2
Name
Retinitis PIgmentosa (RP) disease gene homolog 2
Synonyms
  • CELE_K08D12.2
  • K08D12.2
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity. Involved in protein localization to non-motile cilium. Located in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase).
WB Description
rpi-2 is orthologous to human RP2 (OMIM:312600, mutated in retinitis pigmentosa 2), and paralogous to human TBCC (OMIM:602971) and Y71H2AM.24; RPI-2 localizes to the periciliary membrane compartment beneath the ciliary base.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15440
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
1.7115M1.7120M1.7125M1.7130M1.7135M1.7140M1.7145M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions