Predicted to enable GTPase activator activity. Involved in protein localization to non-motile cilium. Located in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase).
WB Description
rpi-2 is orthologous to human RP2 (OMIM:312600, mutated in retinitis pigmentosa 2), and paralogous to human TBCC (OMIM:602971) and Y71H2AM.24; RPI-2 localizes to the periciliary membrane compartment beneath the ciliary base.