Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within glucose metabolic process and pyruvate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure 70. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2).