Version: 8.0.0
Date: Tue Jan 28 2025
mpz
Danio rerioZFIN:ZDB-GENE-010724-4
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mpz

Species
Danio rerio
Symbol
mpz
Name
myelin protein zero
Synonyms
  • p0
  • sc:d0186
Biotype
protein coding gene
Automated Description
Predicted to be involved in cell-cell adhesion via plasma-membrane adhesion molecules and myelination. Located in myelin sheath. Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple). Orthologous to human MPZ (myelin protein zero).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13869
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMPZ9 of 10YesYes☐ ☑☑☑☑☑☑☑☑ ☑
Mus musculusMpz10 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Rattus norvegicusMpz9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalismpz8 of 9YesYes☐ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
scn2b122445273 of 8☑ ☐☐☐☐☑☑☐ 
mpzl1l217259343 of 8☑ ☐☐☐☐☑☑☐ 
mpzl2b317455353 of 8☑ ☐☐☐☐☑☑☐ 
scn4ba420847283 of 8☑ ☐☐☐☐☑☑☐ 
scn4bb521844253 of 8☑ ☐☐☐☐☑☑☐ 
mpzl3614251352 of 8☐ ☐☐☐☐☑☑☐ 
wu:fu71h0775655302 of 8☐ ☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
whole organism quality, normal
Showing 1 - 1 of 1 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    sa62
    • sa0062
    		allele with one associated variant
    point mutation
    • stop gained
    		Yes
    Showing 1 - 1 of 1 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Danio reriopt408Tg
    Tg1(mpz:mpz-EGFP)
    Danio reriopt409Tg
    Tg1(mpz:mpz-EGFP)
    Danio reriopt410Tg
    Tg1(mpz:mpz-EGFP)
    Danio reriopt411Tg
    Tg1(mpz:mpz-EGFP)
    Danio reriopt412Tg
    Tg2(mpz:mpz-EGFP)
    Danio reriopt418Tg
    Tg3(mpz:mpz-EGFP)
    Danio reriopt419Tg
    Tg4(mpz:mpz-EGFP)
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    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    mpzsa62/sa62 (TL)
    has condition:
    standard conditions
    • whole organism quality, normal
    		ZFIN
    mpzsa62ZFIN
    Showing 1 - 2 of 2 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available