Gene

reln

Species
Danio rerio
Symbol
reln
Name
reelin
Synonyms
None
Biotype
protein coding gene
Automated Description
Predicted to enable lipoprotein particle receptor binding activity. Acts upstream of or within cerebellar Purkinje cell layer morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space and neuron projection. Is expressed in immature eye and nervous system. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensRELN1 of 10YesYes  
Mus musculusReln1 of 10YesYes  

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
Bergmann glial cell inserted into granular layer corpus cerebelli, abnormal
brain ab1-reln labeling absent, abnormal
cerebellar crest reln expression absent, abnormal
cerebellar granule cell reln expression absent, abnormal
cerebellar granule cell differentiation normal occurrence, normal
cerebellar Purkinje cell differentiation normal occurrence, normal
cerebellar Purkinje cell layer morphogenesis decreased occurrence, abnormal
cerebellum has normal numbers of parts of type eurydendroid cell, normal
eurydendroid cell inserted into granular layer corpus cerebelli, abnormal
granular layer corpus cerebelli has extra parts of type Bergmann glial cell, abnormal
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
nub23allele with one associated variantYes
ic3032allele with one associated variantYes
sa23393allele with one associated variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
relnic3032/ic3032
has condition:
standard conditions
  • tectal neuropile reln expression decreased amount, abnormal
ZFIN
relnic3032/ic3032
has condition:
standard conditions
  • brain ab1-reln labeling absent, abnormal
  • hindbrain serotonin increased amount, abnormal
ZFIN
relnic3032/ic3032
has condition:
chemical treatment by environment risperidone
  • social behavior process quality, abnormal
ZFIN
relnic3032/ic3032
has condition:
chemical treatment by injection oxytocin
  • social behavior process quality, abnormal
ZFIN
relnic3032/ic3032
has condition:
chemical treatment by environment buspirone
  • social behavior process quality, abnormal
ZFIN
relnic3032/ic3032 (AB)
has condition:
standard conditions
  • Purkinje cell inserted into granular layer corpus cerebelli, abnormal
  • Purkinje cell layer corpus cerebelli has fewer parts of type Purkinje cell, abnormal
ZFIN
relnic3032/ic3032; s356tTg
has condition:
standard conditions
  • retinal ganglion cell neuron projection mislocalised, abnormal
ZFIN
relnnub23/nub23 (AB)
has condition:
standard conditions
  • Purkinje cell inserted into granular layer corpus cerebelli, abnormal
  • Purkinje cell layer corpus cerebelli has fewer parts of type Purkinje cell, abnormal
ZFIN
relnnub23/nub23; nkhspGFFDMC156AEt; nkuasgfp1aTg (AB)
has condition:
standard conditions
  • Purkinje cell layer corpus cerebelli has fewer parts of type eurydendroid cell, abnormal
  • cerebellum has normal numbers of parts of type eurydendroid cell, normal
ZFIN
relnnub23/nub23; nkhspGFFDMC28CEt; nkuasgfp1aTg (AB)
has condition:
standard conditions
  • Purkinje cell inserted into granular layer corpus cerebelli, abnormal
  • granular layer corpus cerebelli has extra parts of type Purkinje cell, abnormal
ZFIN
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Sequence Feature Viewer

No data available

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available