Version: 8.0.0
Date: Tue Jan 28 2025
wdr36
Danio rerioZFIN:ZDB-GENE-030131-464
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

wdr36

Species
Danio rerio
Symbol
wdr36
Name
WD repeat domain 36
Synonyms
  • TA-WDRP-like
  • wu:fb33e10
Biotype
protein coding gene
Automated Description
Acts upstream of or within rRNA processing. Located in cytoplasm and nucleolus. Is expressed in digestive system; heart; immature eye; nervous system; and somite. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22840
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensWDR3610 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Mus musculusWdr369 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☐
Rattus norvegicusWdr369 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicaliswdr368 of 9YesYes☐ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterCG97999 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☐
Caenorhabditis elegansY45F10D.79 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeUTP219 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
anatomical system quality, abnormal
ciliary marginal zone decreased size, abnormal
ciliary marginal zone nucleolus increased size, abnormal
ciliary marginal zone nucleolus morphology, abnormal
exit from mitosis delayed, abnormal
eye decreased size, abnormal
gut hypoplastic, abnormal
gut quality, abnormal
head decreased size, abnormal
lens degenerate, abnormal
Showing 1 - 10 of 26 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    la025179Tg
    • la025179
    		allele
    hi3630aTg
    • hi3630a
    		allele
    		Yes
    sa14176allele with one associated variant
    point mutation
    • stop gained
    sa33722allele with one associated variant
    point mutation
    • splice donor variant
    Showing 1 - 4 of 4 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    tp53zdf1/zdf1 + MO1-wdr36
    has condition:
    standard conditions
    • eye decreased size, abnormal
    • head decreased size, abnormal
    		ZFIN
    wdr36hi3630aTg/+
    has condition:
    standard conditions
    • retina morphology, normal
    		ZFIN
    wdr36hi3630aTg/hi3630aTg
    has condition:
    standard conditions
    • ciliary marginal zone decreased size, abnormal
    • ciliary marginal zone nucleolus increased size, abnormal
    		ZFIN
    wdr36hi3630aTg
    has condition:
    standard conditions
    • anatomical system quality, abnormal
    • eye decreased size, abnormal
    		ZFIN
    WT + MO1-wdr36
    has condition:
    standard conditions
    • ciliary marginal zone nucleolus increased size, abnormal
    • ciliary marginal zone nucleolus morphology, abnormal
    		ZFIN
    WT + MO2-wdr36
    has condition:
    standard conditions
    • eye decreased size, abnormal
    • head decreased size, abnormal
    		ZFIN
    wdr36hi3630aTg/+ (AB)ZFIN
    wdr36hi3630aTg/+ (AB/TU)ZFIN
    WT + MO1-wdr36 + MO3-tp53ZFIN
    WT + MO1-wdr36 + MO4-tp53ZFIN
    Showing 1 - 10 of 10 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Transcript: Mode:

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available