Version: 8.0.0
Date: Tue Jan 28 2025
dync1h1
Danio rerioZFIN:ZDB-GENE-030131-7050
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

dync1h1

Species
Danio rerio
Symbol
dync1h1
Name
dynein, cytoplasmic 1, heavy chain 1
Synonyms
  • fk70a07
  • wu:fk70a07
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Acts upstream of or within with a positive effect on regulation of cell activation and regulation of microtubule cytoskeleton organization. Acts upstream of or within camera-type eye photoreceptor cell differentiation and central nervous system myelination. Predicted to be located in cytoplasm and microtubule. Predicted to be part of axonemal dynein complex. Is expressed in eye photoreceptor cell; photoreceptor outer segment layer; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

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        Associated Human Diseases
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          Sequence Feature Viewer

          No data available

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          dync1h1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            dync1h1 role
            dync1h1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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