Enables extracellular matrix binding activity. Acts upstream of or within several processes, including neural crest formation; otic placode formation; and regulation of BMP signaling pathway. Located in extracellular matrix and extracellular space. Is expressed in several structures, including head; hematopoietic system; mesoderm; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator).