Version: 8.0.0
Date: Tue Jan 28 2025
mcl1b
Danio rerioZFIN:ZDB-GENE-030825-1
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mcl1b

Species
Danio rerio
Symbol
mcl1b
Name
MCL1 apoptosis regulator, BCL2 family member b
Synonyms
  • zgc:109763
Biotype
protein coding gene
Automated Description
Predicted to enable channel activity. Acts upstream of or within chordate embryonic development and negative regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in mitochondrial outer membrane. Is expressed in brain; digestive system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCz11
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mcl1b molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            mcl1b role
            mcl1b genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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