Version: 8.0.0Date: Tue Jan 28 2025
Gene
clic5b
- Species
- Danio rerio
- Symbol
- clic5b
- Name
- chloride intracellular channel 5b
- Synonyms
- clic5
- clic5a
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable chloride channel activity and oxidoreductase activity. Acts upstream of or within cilium assembly and pronephros development. Predicted to be located in cytoplasm and membrane. Predicted to be part of chloride channel complex. Is expressed in digestive system; immature eye; pectoral fin bud; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to human CLIC5 (chloride intracellular channel 5).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- Not Available
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | CLIC5 | 8 of 10 | Yes | Yes | ☑ ☑☑☐☑☑☑☐☑ ☑ |
| Mus musculus | Clic5 | 6 of 10 | Yes | No | ☑ ☑☑☐☑☑☐☐☐ ☑ |
| Rattus norvegicus | Clic5 | 6 of 9 | Yes | No | ☑ ☑☑☐☑☑☐☐☑ |
| Xenopus tropicalis | clic5 | 5 of 9 | Yes | No | ☑ ☑☐☐☑☑☑☐☐ |
| Drosophila melanogaster | Clic | 7 of 10 | Yes | No | ☑ ☑☑☐☑☑☐☑☑ ☐ |
| Caenorhabditis elegans | exl-1 | 6 of 9 | Yes | No | ☑ ☐☑☐☑☑☐☑☑ |
| Caenorhabditis elegans | exc-4 | 6 of 9 | Yes | No | ☑ ☑☑☐☑☑☐☑☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| clic5a | 1 | 245 | 91 | 81 | 6 of 8 | ☑ ☑☐☑☑☐☑☑ |
| clic4 | 2 | 278 | 81 | 73 | 5 of 8 | ☑ ☑☐☑☑☐☑☐ |
| clic1 | 3 | 236 | 81 | 69 | 5 of 8 | ☑ ☑☐☑☑☐☑☐ |
| clic2 | 4 | 235 | 78 | 63 | 5 of 8 | ☑ ☑☐☑☑☐☑☐ |
| gsto2 | 5 | 216 | 39 | 24 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| gsto1 | 6 | 165 | 42 | 25 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| gstz1 | 7 | 212 | 34 | 16 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
Phenotypes
- Primary Sources
- Other Sources
- None
Phenotype Term | Annotation details | References |
|---|---|---|
| brain hydrocephalic, abnormal | ||
| heart looping process quality, abnormal | ||
| otolith development process quality, abnormal | ||
| otolith mislocalised, abnormal | ||
| pericardium edematous, abnormal | ||
| pronephric glomerulus decreased functionality, abnormal | ||
| pronephric glomerulus functionality, normal | ||
| pronephric tubule Ab3-ezr labeling decreased amount, abnormal | ||
| pronephros cilium assembly decreased process quality, abnormal | ||
| pronephros cilium decreased amount, abnormal |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| AB/TL + MO1-clic5b |
|
| ZFIN | ||
| AB/TL + MO2-clic5b |
|
| ZFIN | ||
| AB/TL + MO3-clic5b |
|
| ZFIN | ||
| li1Tg + MO1-clic5b |
|
| ZFIN | ||
| li1Tg + MO2-clic5b |
|
| ZFIN | ||
| uf4Tg + MO1-clic5b |
|
| ZFIN | ||
| uf4Tg + MO2-clic5b |
|
| ZFIN | ||
| uf4Tg + MO3-clic5b |
|
| ZFIN |
Showing 1 - 8 of 8 rows
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Sequence Feature Viewer
- Genome location
- Chr20:43925266...43968859 (43.59 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction