Version: 8.0.0
Date: Tue Jan 28 2025
park7
Danio rerioZFIN:ZDB-GENE-041010-5
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

park7

Species
Danio rerio
Symbol
park7
Name
parkinson protein 7
Synonyms
  • DJ-1
  • zDJ-1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including glyoxalase (glycolic acid-forming) activity; protein deglycase activity; and protein homodimerization activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; retina homeostasis; and swimming behavior. Predicted to be located in endoplasmic reticulum; membrane raft; and plasma membrane. Predicted to be active in mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Used to study Parkinson's disease and retinal degeneration. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43444
No data available

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            No data available

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            park7 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              park7 role
              park7 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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