Version: 8.0.0
Date: Tue Jan 28 2025
ptgs2b
Danio rerioZFIN:ZDB-GENE-041014-323
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ptgs2b

Species
Danio rerio
Symbol
ptgs2b
Name
prostaglandin-endoperoxide synthase 2b
Synonyms
  • Cox-2b
  • si:dkey-97o5.6
Biotype
protein coding gene
Automated Description
Enables peroxidase activity. Predicted to be involved in cyclooxygenase pathway. Predicted to act upstream of or within prostaglandin biosynthetic process and response to oxidative stress. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including female organism; gonad; kidney; male organism; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; arthritis (multiple); cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11903
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCz11
            Viewer Help
            34.1220M34.1225M34.1230M34.1235M34.1240M34.1245M34.1250M34.1255M34.1260M34.1265M34.1270M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ptgs2b molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              ptgs2b role
              ptgs2b genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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