Version: 8.0.0
Date: Tue Jan 28 2025
pink1
Danio rerioZFIN:ZDB-GENE-041212-53
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pink1

Species
Danio rerio
Symbol
pink1
Name
PTEN induced kinase 1
Synonyms
  • wu:fc39e12
  • zgc:101729
Biotype
protein coding gene
Automated Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and swimming behavior. Located in cytosol and mitochondrion. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22972

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          No data available

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pink1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            pink1 role
            pink1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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