Involved in melanosome organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including caudal fin; central nervous system; gill; heart; and otic vesicle. Used to study vitiligo. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin).