Gene

cyp26c1

Species
Danio rerio
Symbol
cyp26c1
Name
cytochrome P450, family 26, subfamily C, polypeptide 1
Synonyms
  • cyp26b1l
  • cyp26d1
Biotype
protein coding gene
Automated Description
Predicted to enable monooxygenase activity. Acts upstream of or within several processes, including circulatory system development; retinoic acid metabolic process; and rhombomere 4 morphogenesis. Is expressed in several structures, including brain; eye; hindbrain neural keel; optic cup; and pleuroperitoneal region. Orthologous to human CYP26C1 (cytochrome P450 family 26 subfamily C member 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24286
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCYP26C16 of 10YesYes  
Mus musculusCyp26c16 of 10YesYes  
Rattus norvegicusCyp26c15 of 9YesYes   
Xenopus tropicaliscyp26c14 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
cyp26b1155168527 of 8  
cyp26a1254356417 of 8  
cyp51355938222 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
otic vesicle development disrupted, abnormal
otic vesicle morphology, abnormal
pancreas length, normal
pancreas position, normal
pectoral fin shox expression decreased amount, abnormal
pectoral fin decreased size, abnormal
pericardium edematous, abnormal
pharyngeal arch morphology, abnormal
whole organism shox expression decreased amount, abnormal
whole organism retinoic acid increased amount, abnormal
Showing 1 - 10 of 10 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
tpl24Gt
  • Gt(GBT-B1)tpl24
allele
Showing 1 - 1 of 1 rows
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
AB/TL + MO2-shox + MO4-cyp26c1
has condition:
standard conditions
  • pectoral fin decreased size, abnormal
  • pectoral fin development disrupted, abnormal
ZFIN
AB/TL + MO4-cyp26c1
has condition:
standard conditions
  • otic vesicle development disrupted, abnormal
  • otic vesicle morphology, abnormal
ZFIN
ci5Tg; twu34Tg + MO1-cyp26c1 + MO2-cyp26c1 + MO4-cyp26a1 + MO5-cyp26a1
has condition:
standard conditions
  • cardiac ventricle cardiac ventricle morphogenesis decreased process quality, abnormal
  • ventricular myocardium increased distance ventricular endocardium, abnormal
ZFIN
cyp26a1rw716/rw716 + MO1-cyp26b1 + MO1-cyp26c1
has condition:
standard conditions
  • hindbrain wholly posteriorized, abnormal
  • pancreas development process quality, abnormal
ZFIN
cyp26a1rw716/rw716 + MO1-cyp26c1
has condition:
standard conditions
  • heart edematous, abnormal
  • hindbrain edematous, abnormal
ZFIN
cyp26a1rw716/rw716 + MO1-cyp26c1 + MO1-dnd1
has condition:
standard conditions
  • hindbrain morphology, abnormal
  • hindbrain wholly posteriorized, abnormal
ZFIN
f2Tg + MO1-cyp26c1 + MO2-cyp26c1 + MO4-cyp26a1 + MO5-cyp26a1
has condition:
standard conditions
  • cardiac ventricle cardiac ventricle morphogenesis decreased process quality, abnormal
  • cardiac ventricle cardiac ventricle morphogenesis process quality, normal
ZFIN
f2Tg + MO1-cyp26c1 + MO2-cyp26c1 + MO4-cyp26a1 + MO5-cyp26a1
has condition:
chemical treatment by environment 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
  • cardiac ventricle cardiac ventricle morphogenesis process quality, ameliorated
  • cardiac ventricle has number of cardiac muscle cell, ameliorated
ZFIN
f2Tg + MO1-cyp26c1 + MO2-cyp26c1 + MO4-cyp26a1 + MO5-cyp26a1
has condition:
heat shock
  • cardiac muscle cell external to heart, abnormal
  • cardiac ventricle cardiac ventricle morphogenesis decreased process quality, abnormal
ZFIN
f2Tg; pd3Tg + MO1-cyp26c1 + MO2-cyp26c1 + MO4-cyp26a1 + MO5-cyp26a1
has condition:
heat shock
  • cardiac muscle cell external to heart, abnormal
  • cardiac ventricle cardiac ventricle morphogenesis decreased process quality, abnormal
ZFIN
Showing 1 - 10 of 29 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
19.524M19.526M19.528M19.530M19.532M19.534M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available