Version: 8.0.0
Date: Tue Jan 28 2025
drd4-rs
Danio rerioZFIN:ZDB-GENE-051113-172
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

drd4-rs

Species
Danio rerio
Symbol
drd4-rs
Name
dopamine receptor D4 related sequence
Synonyms
  • drd4b
  • si:ch211-69h5.1
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled dopamine receptor signaling pathway; negative regulation of glutamatergic synaptic transmission; and regulation of dopamine secretion. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adenohypophyseal placode; central nervous system; otic vesicle; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44250
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCz11
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          drd4-rs molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            drd4-rs role
            drd4-rs genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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