Species

Danio rerio

Symbol

sgms2a

Name

sphingomyelin synthase 2a

Synonyms

sgms2

Biotype

protein coding gene

Automated Description

Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to act upstream of or within sphingolipid metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Orthologous to human SGMS2 (sphingomyelin synthase 2).

ZFIN Description

Not Available

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR21290

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	SGMS2	10 of 10	Yes	Yes	☑ ☑☑☑☑☑☑☑☑ ☑
Mus musculus	Sgms2	10 of 10	Yes	Yes	☑ ☑☑☑☑☑☑☑☑ ☑
Rattus norvegicus	Sgms2	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Xenopus tropicalis	sgms2	8 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☐
Caenorhabditis elegans	sms-1	5 of 9	Yes	No	☑ ☑☑☐☐☐☑☐☑

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
sgms2b	1	342	74	60	7 of 8	☑ ☑☐☑☑☑☑☑
sgms1a	2	354	69	53	7 of 8	☑ ☑☐☑☑☑☑☑
sgms1b	3	302	77	60	7 of 8	☑ ☑☐☑☑☑☑☑
samd8	4	342	57	39	6 of 8	☑ ☑☐☑☑☑☑☐

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

No data available

Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

No data available

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location

Chr1:49933652...49950643 (16.99 kb)

Assembly version

GRCz11

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available