Gene

aire

Species
Danio rerio
Symbol
aire
Name
autoimmune regulator
Synonyms
  • si:dkey-261l2.5
Biotype
protein coding gene
Automated Description
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including immune system development; negative thymic T cell selection; and regulation of thymocyte migration. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24102
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
22.810M22.815M22.820M22.825M22.830M22.835M22.840M22.845M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions