Version: 8.0.0
Date: Tue Jan 28 2025
itgb3a
Danio rerioZFIN:ZDB-GENE-071207-1
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

itgb3a

Species
Danio rerio
Symbol
itgb3a
Name
integrin beta 3a
Synonyms
  • integrin beta 3.2
  • itgb3.2
Biotype
protein coding gene
Automated Description
Predicted to enable fibronectin binding activity and integrin binding activity. Predicted to contribute to fibrinogen binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; integrin-mediated signaling pathway; and platelet aggregation. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface; focal adhesion; and synapse. Is expressed in brain and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; myocardial infarction; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10082

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          No data available

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          itgb3a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            itgb3a role
            itgb3a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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