Version: 8.0.0Date: Tue Jan 28 2025
Gene
rapgef2a
- Species
- Danio rerio
- Symbol
- rapgef2a
- Name
- Rap guanine nucleotide exchange factor 2a
- Synonyms
- si:dkey-253i9.4
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within cell differentiation and small GTPase-mediated signal transduction. Predicted to be located in several cellular components, including anchoring junction; late endosome; and perinuclear region of cytoplasm. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23113
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | RAPGEF2 | 3 of 10 | Yes | No | ☐ ☐☐☐☐☐☑☑☐ ☑ |
| Mus musculus | Rapgef2 | 3 of 10 | Yes | No | ☐ ☐☐☐☐☐☑☑☐ ☑ |
| Drosophila melanogaster | PDZ-GEF | 7 of 10 | Yes | No | ☑ ☑☑☐☑☑☑☐☑ ☐ |
| Caenorhabditis elegans | pxf-1 | 8 of 9 | Yes | Yes | ☑ ☑☑☑☐☑☑☑☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| rapgef2b | 1 | 1623 | 75 | 64 | 8 of 8 | ☑ ☑☑☑☑☑☑☑ |
| rapgef6 | 2 | 1587 | 67 | 53 | 6 of 8 | ☐ ☑☐☑☑☑☑☑ |
| sos2 | 3 | 1429 | 34 | 21 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rapgef4a | 4 | 1279 | 38 | 23 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgrf2b | 5 | 1284 | 34 | 19 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rapgef3 | 6 | 1143 | 37 | 21 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgrf1 | 7 | 1321 | 33 | 17 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgrf2a | 8 | 1259 | 32 | 19 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rapgef1b | 9 | 1156 | 32 | 19 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rgl2 | 10 | 866 | 35 | 21 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| ralgds | 11 | 902 | 35 | 20 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| rapgef5a | 12 | 776 | 36 | 24 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rgl1 | 13 | 767 | 35 | 23 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rgl3a | 14 | 805 | 35 | 19 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgef1ba | 15 | 546 | 39 | 24 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgrp3 | 16 | 624 | 33 | 19 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rapgefl1 | 17 | 434 | 44 | 28 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rapgef1a | 18 | 470 | 41 | 25 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| ralgps1 | 19 | 490 | 37 | 22 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgrp2 | 20 | 444 | 38 | 19 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| ralgps2 | 21 | 445 | 40 | 21 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| rapgef4b | 22 | 394 | 39 | 23 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgef1bb | 23 | 352 | 43 | 26 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rapgef5b | 24 | 385 | 31 | 20 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rasgrp4 | 25 | 349 | 36 | 21 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr1:21138820...21204114 (65.29 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| zko405a | allele | ||||||
| sa38258 | allele with one associated variant | point mutation
| |||||
| sa14351 | allele with one associated variant | point mutation
| |||||
| sa19478 | allele with one associated variant | point mutation
| |||||
| sa32653 | allele with one associated variant | point mutation
| |||||
| sa11830 | allele with one associated variant | point mutation
| |||||
Showing 1 - 6 of 6 rows
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Sequence Feature Viewer
- Genome location
- Chr1:21138820...21204114 (65.29 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction