Version: 8.0.0
Date: Tue Jan 28 2025
frk
Danio rerioZFIN:ZDB-GENE-110411-7
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

frk

Species
Danio rerio
Symbol
frk
Name
fyn-related Src family tyrosine kinase
Synonyms
  • frk
  • frka
Biotype
protein coding gene
Automated Description
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within cranial skeletal system development. Predicted to be active in plasma membrane. Is expressed in oral epithelium and pharyngeal arch cartilage. Orthologous to human FRK (fyn related Src family tyrosine kinase).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24418
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFRK10 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Mus musculusFrk10 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Rattus norvegicusFrk9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisfrk9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterSrc42A8 of 10YesYes☑ ☑☑☑☑☑☑☐☑ ☐
Caenorhabditis eleganssrc-27 of 9YesYes☑ ☑☑☐☑☑☑☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
yrk148070554 of 8☑ ☐☐☑☐☑☑☐ 
src251365494 of 8☑ ☐☐☑☐☑☑☐ 
fynb344872564 of 8☑ ☐☐☑☐☑☑☐ 
fyna344872564 of 8☑ ☐☐☑☐☑☑☐ 
yes1444772564 of 8☑ ☐☐☑☐☑☑☐ 
lck551065464 of 8☑ ☐☐☑☐☑☑☐ 
hck646568534 of 8☑ ☐☐☑☐☑☑☐ 
blk746169524 of 8☑ ☐☐☑☐☑☑☐ 
ptk6b852157425 of 8☑ ☑☐☑☐☑☑☐ 
srms949960405 of 8☑ ☑☐☑☐☑☑☐ 
ptk6a1050257415 of 8☑ ☑☐☑☐☑☑☐ 
abl11149160434 of 8☑ ☐☐☑☐☑☑☐ 
abl21246761444 of 8☑ ☐☐☑☐☑☑☐ 
si:ch73-340m8.21344461425 of 8☑ ☑☐☑☐☑☑☐ 
itk1451254374 of 8☑ ☐☐☑☐☑☑☐ 
tec1549854365 of 8☑ ☑☐☑☐☑☑☐ 
txk1651056383 of 8☐ ☐☐☑☐☑☑☐ 
btk1748554384 of 8☑ ☐☐☑☐☑☑☐ 
csk1846156394 of 8☑ ☐☐☑☐☑☑☐ 
fer1947055364 of 8☑ ☐☐☑☐☑☑☐ 
fes2049350344 of 8☑ ☐☐☑☐☑☑☐ 
matk2144953344 of 8☑ ☐☐☑☐☑☑☐ 
syk2245550324 of 8☑ ☑☐☐☐☑☑☐ 
ptk2ab2349747283 of 8☑ ☐☐☐☐☑☑☐ 
zap702443650313 of 8☑ ☐☐☐☐☑☑☐ 
ptk2ba2543047313 of 8☑ ☐☐☐☐☑☑☐ 
jak2b2645248302 of 8☑ ☐☐☐☐☐☑☐ 
tnk2b2739947323 of 8☑ ☐☐☐☐☑☑☐ 
jak12843547302 of 8☑ ☐☐☐☐☐☑☐ 
tnk12938449313 of 8☑ ☐☐☐☐☑☑☐ 
tyk23043046302 of 8☑ ☐☐☐☐☐☑☐ 
jak33144444282 of 8☑ ☐☐☐☐☐☑☐ 
jak2a3243845282 of 8☑ ☐☐☐☐☐☑☐ 
si:ch73-206d17.13341542273 of 8☑ ☐☐☐☐☑☑☐ 
tnk2a3428256383 of 8☑ ☐☐☐☐☑☑☐ 
styk1a3536548302 of 8☐ ☐☐☐☐☑☑☐ 
ptk2bb3629452363 of 8☑ ☐☐☐☐☑☑☐ 
araf3735945302 of 8☐ ☑☐☐☐☐☑☐ 
raf1b3830151322 of 8☐ ☑☐☐☐☐☑☐ 
raf1a3928251332 of 8☐ ☑☐☐☐☐☑☐ 
braf4027852322 of 8☐ ☑☐☐☐☐☑☐ 
styk1b4124452323 of 8☑ ☐☐☐☐☑☑☐ 
sla2a4221649342 of 8☐ ☐☐☑☐☐☑☐ 
grap2b4323444272 of 8☐ ☐☐☑☐☐☑☐ 
grap2a4419349342 of 8☐ ☐☐☑☐☐☑☐ 
sla1a4515651372 of 8☐ ☐☐☐☐☑☑☐ 
grapa4614455402 of 8☐ ☐☐☑☐☐☑☐ 
grb2b4714257372 of 8☐ ☐☐☑☐☐☑☐ 
grb2a4814257362 of 8☐ ☐☐☑☐☐☑☐ 
grapb4914151352 of 8☐ ☐☐☑☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
ceratobranchial cartilage disorganized, abnormal
ceratobranchial cartilage hypoplastic, abnormal
ceratohyal cartilage increased angle to ceratohyal cartilage, abnormal
cranial skeletal system development disrupted, abnormal
eye increased distance eye, abnormal
head flattened, abnormal
Meckel's cartilage morphology, abnormal
Meckel's cartilage-palatoquadrate cartilage joint morphology, abnormal
otolith decreased distance otolith, abnormal
otolith decreased size, abnormal
Showing 1 - 10 of 10 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    sa43361allele with one associated variant
    point mutation
    • missense variant
    Showing 1 - 1 of 1 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    WT + MO1-frk + MO2-frk
    has condition:
    standard conditions
    • Meckel's cartilage morphology, abnormal
    • Meckel's cartilage-palatoquadrate cartilage joint morphology, abnormal
    		ZFIN
    Showing 1 - 1 of 1 rows
    per page

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available