Version: 8.0.0Date: Tue Jan 28 2025
Gene
nras
- Species
- Danio rerio
- Symbol
- nras
- Name
- NRAS proto-oncogene, GTPase
- Synonyms
- etID18709.8
- fj99a10
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24070
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | NRAS | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Mus musculus | Nras | 7 of 10 | Yes | Yes | ☑ ☑☐☑☑☐☑☑☐ ☑ |
| Rattus norvegicus | Nras | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | nras | 5 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☑☐ |
| Drosophila melanogaster | Ras85D | 7 of 10 | Yes | No | ☐ ☑☑☑☐☑☑☑☑ ☐ |
| Caenorhabditis elegans | let-60 | 7 of 9 | Yes | No | ☐ ☑☑☑☐☑☑☑☑ |
| Saccharomyces cerevisiae | RAS2 | 3 of 9 | Yes | No | ☑ ☐☑☐☐☐☐☐☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| hrasb | 1 | 188 | 93 | 87 | 8 of 8 | ☑ ☑☑☑☑☑☑☑ |
| hrasa | 2 | 188 | 92 | 87 | 8 of 8 | ☑ ☑☑☑☑☑☑☑ |
| kras | 3 | 190 | 92 | 84 | 8 of 8 | ☑ ☑☑☑☑☑☑☑ |
| zgc:55558 | 4 | 178 | 94 | 87 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| rap1ab | 5 | 185 | 74 | 55 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| rap1aa | 6 | 185 | 74 | 55 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| rras | 7 | 190 | 69 | 54 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| rras2 | 8 | 186 | 71 | 55 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| rap1b | 9 | 183 | 72 | 55 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| rap2ab | 10 | 189 | 69 | 45 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| ralab | 11 | 179 | 75 | 54 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rap2c | 12 | 189 | 68 | 44 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| rap2b | 13 | 190 | 67 | 44 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| ralaa | 14 | 179 | 74 | 54 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| mrasa | 15 | 195 | 65 | 52 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| mrasb | 16 | 195 | 65 | 51 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| ralba | 17 | 176 | 73 | 51 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| rit1 | 18 | 174 | 69 | 48 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| diras1a | 19 | 190 | 59 | 36 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| diras1b | 20 | 197 | 56 | 35 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| rhebl1 | 21 | 189 | 57 | 36 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| rerg | 22 | 171 | 59 | 44 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| nkiras2 | 23 | 185 | 51 | 32 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
| rasd4 | 24 | 168 | 59 | 32 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| rasl12 | 25 | 167 | 54 | 34 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| rasd3 | 26 | 172 | 53 | 32 | 2 of 8 | ☑ ☐☐☐☐☑☐☐ |
| nkiras1 | 27 | 178 | 50 | 30 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
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Sequence Feature Viewer
- Genome location
- Chr8:11114754...11131695 (16.94 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction