Allele/Variant

Il1raptm1Roml

Species
Mus musculus
Symbol
Il1raptm1Roml
Category
allele
Allele of gene
Il1rap
Transgenic Constructs
None
Synonyms
  • IL-1RAcP-
  • IL1 receptor AcP KO
Description
A neomycin resistance cassette replaced a genomic fragment containing exons D1 and part of D2A. These exons encode the first Ig domain and part of the second Ig domain. Northern blot analysis revealed that a truncated mRNA was produced from this allele, but equilibrium binding studies demonstrated that no protein was present on the cell surface of primary mouse embryo fibroblasts (PMEFs) derived from homozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations