Allele/Variant

Tg(Ins2-cre)25Mgn

Species
Mus musculus
Symbol
Tg(Ins2-cre)25Mgn
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • [RIP]-Cre
  • Ins-Cre
Description
This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. Transgene insertion occurred on Chr 7, causing a 17400 bp duplication.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal circulating insulin levelMGI
abnormal insulin secretionMGI
decreased insulin secretion
MGI
impaired glucose toleranceMGI
Showing 1 - 4 of 4 rows
per page

Disease Associations

No data available