Allele/Variant

Cst3tm1Karl

Species
Mus musculus
Symbol
Cst3tm1Karl
Category
allele
Allele of gene
Cst3
Transgenic Constructs
None
Synonyms
  • CstC-
  • Cstc-
Description
An attempted knockin resulted in the generation of a null mouse. The majority of exon 1 was replaced by a human Cst3 cDNA fragment containing a missense mutation that substitutes a glutamine for a leucine at codon 68. In addition, a neomycin selection cassette was inserted at the 3' end of exon 1 and replaced two thirds of intron 1. Northern blot analysis using probes for both the human and mouse transcript showed an absence of both transcripts in lung, heart, testis, kidney and brain tissues obtained from homozygous mutant mice. ELIZA using human- and mouse-specific antibodies failed to detect either protein in homozygous mutant animals.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
decreased susceptibility to ischemic brain injuryMGI
increased cerebral infarct sizeMGI
increased metastatic potential
MGI
loss of hippocampal neuronsMGI
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Disease Associations

No data available