Allele/Variant

Pafah1b1Gt(IRESBetageo)1Hha

Species
Mus musculus
Symbol
Pafah1b1Gt(IRESBetageo)1Hha
Category
allele
Allele of gene
Pafah1b1
Transgenic Constructs
None
Synonyms
  • LIS1GT/GT
Description
The expression of a testis-specific transcript was abrogated by the integration a gene trap vector into the endogenous locus. The vector inserted into intron 2 and consisted of an engrailed 2 intron, IRES, and beta-geo. RT-PCR analysis showed the level of a testis-specific transcript, containing exon 2a, to be markedly diminished in homozygous mutant mice. While protein was detected in homozygous mutant brain tissue by Western blot analysis, it was absent in the testes of mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Disease Associations