Allele/Variant

Tg(Wap-rtTA-cre)10Whl

Species
Mus musculus
Symbol
Tg(Wap-rtTA-cre)10Whl
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • TgWAPrtTACre
  • Wap-cre
Description
Sequence encoding reverse tetracycline-controlled transactivator (rtTA) was placed under control of the whey acidic protein promoter and in cis configuration with sequence encoding cre recombinase adjoined to an rtTA-inducible CMV promoter. Initial reporter analysis showed cre activity to be completely doxycycline dependent and restricted to the mammary epithelial cells. In contrast, subsequent activity analysis in J:90247 showed doxycycline independent cre activity in a variety of tissues including the mammary gland, brain, liver, and spleen; putatively due to a modification of the transgene and/or the unstable nature of transgene copy number.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
  • Wap
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations