Allele/Variant

Dntttm1Tok

Species
Mus musculus
Symbol
Dntttm1Tok
Category
allele
Allele of gene
Dntt
Transgenic Constructs
None
Synonyms
  • lckTdT+
Description
A PGK-neomycin resistance cassette replaced the endogenous promoter with the lck promoter, which is active in developing thymus. Northern blot analysis using a full length cDNA probe detected Dntt transcript in thymus of homozygous mutant E14.5-E18.5 embryos and in adults, as well as in homozygous mutant adult spleen, bone marrow, lymph node and lung, but not in mutant adult kidney, brain or liver. The Dntt expression pattern observed in the mutant mice was identical to that of the Lck gene in normal mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations