Allele/Variant

Cpa3tm2Hrr

Species
Mus musculus
Symbol
Cpa3tm2Hrr
Category
allele
Allele of gene
Cpa3
Transgenic Constructs
None
Synonyms
  • Mc-cpaY356L,E378A
Description
The endogenous gene has been mutated by homologous recombination to contain two point mutations in exon 11, A1073T and A1139C (per NCBI Entrez mRNA NM_007753), and thus to encode a protein harboring the amino-acid substitutions Tyr356Leu and Glu378Ala, respectively. A single loxP site remains in intron 10. Although western blot analysis of lysates of peritoneal mast cells demonstrates that mast cells from homozygous mutant mice express ~80% as much protein as those from normal mice, the lysates contain no detectable carboxypeptidase activity against the test substrate N-[4-methoxyphenylazoformyl]-Phe-OH.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations