Allele/Variant

Tg(SFTPC-EML4/ALK)502-4Hima

Species
Mus musculus
Symbol
Tg(SFTPC-EML4/ALK)502-4Hima
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • EML4-ALK
Description
The human SFTPC promoter was used to drive lung-specific expression of a flag-tagged human fusion generated in human non-small-cell lung cancer due to recurrent chromosome inversion, inv(2)(p21p23). Two lines were created (502-4 and 501-3) that exhibit identical tumor-forming activity. Line 502-4 was selected as the representative line. Line 502-4 carried 30 copies of the transgene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
increased lung adenocarcinoma incidence
MGI
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Disease Associations

Association
Disease Qualifier
Disease
Annotation details
Evidence
Source
References
is implicated inlung cancer
  • TAS
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