Allele/Variant

Muc1tm1.1(cre/ERT2)Lcm

Species
Mus musculus
Symbol
Muc1tm1.1(cre/ERT2)Lcm
Category
allele
Allele of gene
Muc1
Transgenic Constructs
Synonyms
  • Muc1IC2
  • Muc1IRES-CreERT2
Description
This allele was derived by crossing mice bearing Muctm1(cre/ERT2)Lcm to Gt(ROSA)26Sortm1(FLP1)Dym mice to delete the frt site-flanked neomycin resistance cassette in the germline. The present, neo-, allele contains, downstream of the termination codon of the endogenous gene, an internal ribosomal entry site (IRES) followed by DNA encoding Cre recombinase joined to ERT2 and a single frt site (IRES-CreERT2-FRT). ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain (LBD) that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands. The cre/ERT2 fusion protein is expressed under control of the endogenous promoter without disrupting expression of the endogenous gene. Tamoxifen-induced Cre activity has been demonstrated in acinar and ductal cells of the adult pancreas and in their embryonic precursors.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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