Allele/Variant

Tg(FXN)YG22Pook

Species
Mus musculus
Symbol
Tg(FXN)YG22Pook
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • YG22
Description
The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG22 was generated, showing a reduced transmission rate of 21%, indicating germ-line mosaicism of the transgene, compared to 52% transmission to offspring for founder line YG8. One copy of the FXN gene was detected, and contains a single 190 GAA repeat sequence.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations