Allele/Variant

Pdcd4tm1.1Tosc

Species
Mus musculus
Symbol
Pdcd4tm1.1Tosc
Category
allele
Allele of gene
Pdcd4
Transgenic Constructs
None
Synonyms
  • pdcd4delta2,3
Description
An frt flanked neomycin cassette with a 5' attached loxP site was inserted in intron 3. An additional loxP site was inserted in intron 1. Exons 2 and 3 of the resulting allele are thus flanked by loxP sites. Mice were crossed to transgenic mice carrying a beta actin-cre to excise exons 2 and 3. This results in a frameshift mutation creating a stop site at codon 16. The resulting mice retain the frt flanked neomycin resistance cassette.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations