Allele/Variant

Tg(Thy1-APPSwe)1Lngn

Species
Mus musculus
Symbol
Tg(Thy1-APPSwe)1Lngn
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • tg-APPSwe
  • TgSwe
Description
A human amyloid beta (A4) precursor protein cDNA sequence (APP695) was altered to include the APP KM670/671NL (Swedish) Familial Alzheimer's Disease (FAD) mutation. The resultant APPSwe construct was then placed downstream of the mouse thymus cell antigen 1, theta [Thy1] promoter (via insertion into the ATG start site in exon 2 of the mouse Thy1 locus in the Thy-1323-cassette). The resulting transgene was microinjected into (C57BL/6xCBA)F1 pronuclear oocytes. Two founder lines were generated and one line displaying 3-fold overexpression of human APP in the brain was analyzed further.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
amyloid beta deposits
MGI
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Disease Associations

No data available