Allele/Variant

Tg(TTR-INSR)L3Dac

Species
Mus musculus
Symbol
Tg(TTR-INSR)L3Dac
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
A human insulin receptor cDNA was inserted in exon 3 of a 3kbp human TTR fragment containin the promoter and exons 1-3. The insulin receptor cDNA is thus placed under the control of the human TTR promoter. Three founder lines were established (L1, L2, L3). Highest expression was found in L1. Expression in L3 which has a copy number of 1 was 29% of expression in L1.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations