Allele/Variant

Tg(RP11-209M4*)#Gglo

Species
Mus musculus
Symbol
Tg(RP11-209M4*)#Gglo
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • SOSTvbdelta
  • Tg(RP11-209M4VBD)
Description
The transgene contains human BAC RP11-209M4 in which 52 KB between the 3' end of MEOX1 and SOST are removed. This region is removed in human patients with Van Buchem disease. Three lines were generated (A, B, and an unnamed line). RT-PCR and quantitative PCR confirmed that all lines express human SOST in the mineralized bone of neonatal and adult mice (skull, rib, and femur) and in the adult kidney and heart at a lesser amount than in mice expressing the wild-type BAC. No expression of human Meox was detected. The pound symbol (#) is used when no line is specified and/or lines are pooled.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations